【Williams血液學】（第9版）（英文版）

經典名著《Williams血液學》是血液學領域公認的經典之作，經過多次修訂，指導了一代又一代的臨床醫生、生物學研究者和眾多學科的實習生。 作者們均是各自領域的學術帶頭人，他們的基礎和臨床成果得到了國際廣泛認可。

內容全面共139章，涵蓋了血液學的所有方面。 前半部分討論了患者臨床評估、血液病的分子學和細胞學基礎，後半部分具體闡述了紅細胞疾病、粒細胞和單核細胞疾病、淋巴細胞和漿細胞疾病、髓系腫瘤性疾病、淋巴組織疾病、止血和血栓，以及輸血醫學。 包含彩圖1300餘幅。

與時俱進《Williams血液學（第9版）》在基礎科學、轉換病理生理學和臨床實踐方面做了大篇幅的修改和更新，以反映血液學領域*的研究進展。

印刷精美全書彩色印刷，包含大量極具診斷價值的細胞形態學圖片，使閱讀和查找更加直觀、方便。

內容簡介

《Williams血液學》是血液學領域的經典之作，涵蓋了血液學的所有方面，介紹了患者臨床評估、血液病的分子學和細胞學基礎，並具體闡述了紅細胞疾病、粒細胞和單核細胞疾病、淋巴細胞和漿細胞疾病、髓系腫瘤性疾病、淋巴組織疾病、止血和血栓、輸血醫學等內容。 第9版在第8版的基礎上做了大篇幅的修改和更新，以反映血液學領域的*進展。 新新增了表觀遺傳學和基因組學、血液腫瘤細胞的新陳代謝和肝素誘導性血小板減少症等內容。 本書是血液科臨床醫生、實習生、血液學研究人員必不可少的案頭佳作，也是學習血液學專業英語的工具書。

作者簡介

考杉斯基（Kaushansky）博士是紐約州立大學石溪分校健康科學院的高級副總裁，同時擔任該校醫學院院長的職務。 考杉斯基（Kaushansky）博士是全球知名的血液學專家，發表過多篇有影響力的著作。 擔任《Willians血液學》第8版、第9版的主編。

目錄

簡目

Contributors

Preface

PART IClinical Evaluation of the Patient

PARTII  TheOrganization of the LymphohematopoieticTissues

PARTIII  EpochalHematology

PARTIV  Molecular and CellularHematology

PARTV  TherapeuticPrinciples

PARTVI  The Erythrocyte

PARTVII  Neutrophils,Eosinophils,Basophils, and Mast Cells

PARTVIII  Monocytes and Macrophages

PARTIX  Lymphocytes and Plasma Cells

PARTX  MalignantMyeloid Diseases

PARTXI  MalignantLymphoid Diseases

PARTXII  Hemostasis andThrombosis

PARTXIII  Transfusion Medicine

Index

v

目錄

Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix

Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xxi

PART I

ClinicalEvaluation of the Patient

1.InitialApproachto the Patient:HistoryandPhysicalExamination

2.Examinationof Blood Cells

3.ExaminationofTheMarrow

4.ConsultativeHematology

PART II

TheOrganization of the LymphohematopoieticTissues

5.Structureof the Marrowand the HematopoieticMicroenvironment

6.The Organization and StructureofLymphoid Tissues

PART III

Epochal Hematology

7.Hematologyof the FetusandNewborn

8.HematologyduringPregnancy

9.Hematology in OlderPersons

PART IV

Molecular and CellularHematology

10.Genetic PrinciplesandMolecular Biology

11.Genomics

12.Epigenetics

13.Cytogeneticsand Genetic Abnormalities

14.MetabolismofHematologicNeoplastic Cells

15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem

16.Cell-CycleRegulationandHematologicDisorders

17.SignalTransductionPathways

18.HematopoieticStem Cells，Progenitors，andCytokines

19.TheInflammatory Response

20.InnateImmunity

21.Dendritic Cells andAdaptiveImmunity

PARTV

TherapeuticPrinciples

22.PharmacologyandToxicityofAntineoplastic Drugs

23.Hematopoietic Cell Transplantation

24.Treatment of InfectionsinTheImmunocompromisedHost

25.AntithromboticTherapy

26.Immune Cell Therapy

27.VaccineTherapy

28.TherapeuticApheresis:Indications，Efficacy，andComplications

29.Gene TherapyforHematologicDiseases

30.RegenerativeMedicine:MultipotentialCellTherapy for

TissueRepair

PARTVI

The Erythrocyte

31.StructureandCompositionof the Erythrocyte

32.Erythropoiesis

33.Erythrocyte Turnover

34.ClinicalManifestations and Classification ofErythrocyteDisorders

35.AplasticAnemia:Acquiredand Inherited.

36. Pure Red Cell Aplasia

37. Anemia of ChronicDisease

38. The Congenital DyserythropoieticAnemias

39. Paroxysmal Nocturnal Hemoglobinuria

40. ParoxysmalNocturnalHemoglobinuria

41. Folate，Cobalamin，andMegaloblasticAnemias

42.IronMetabolism

43.Iron Deficiency andOverload

44. Anemia Resulting fromOtherNutritionalDeficiencies

45. Anemia AssociatedwithMarrowInfiltration

46. Erythrocyte MembraneDisorders

47. Erythrocyte Enzyme Disorders

48. TheThalassemias: Disorders of GlobinSynthesis

49. DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalities

50. Methemoglobinemiaand Other Dyshemoglobinemias

51. FragmentationHemolyticAnemia

52. Erythrocyte Disordersas a ResultofChemicalandPhysicalAgents

53. HemolyticAnemiaResultingfromInfectionswithMicroorganisms

54. HemolyticAnemiaResultingfromImmuneInjury

55. AlloimmuneHemolytic Disease of the FetusandNewborn

56. HypersplenismandHyposplenism

57. Primary and Secondary Erythrocytoses

58.ThePorphyrias

59.PolyclonalandHereditarySideroblasticAnemias

PARTVII

Neutrophils,Eosinophils,Basophils, and Mast Cells

60. StructureandCompositionofNeutrophils，Eosinophils，andBasophils

61. Production，Distribution，andFateofNeutrophils

62. EosinophilsandRelatedDisorders

63. Basophils，Mast Cells，andRelatedDisorders

64. Classificationand Clinical ManifestationsofNeutrophilDisorders

65. NeutropeniaandNeutrophilia

66. DisordersofNeutrophilFunction

PARTVIII

Monocytes and Macrophages

67. Structure，Receptors，andFunctionsofMonocytesandMacrophages

68. Production， Distribution,andActivationofMonocytesandMacrophages

69. Classificationand ClinicalManifestationsof DisordersofMonocytesandMacrophages

70. MonocytosisandMonocytopenia

71. Inflammatory andMalignantHistiocytosis

72. Gaucher Disease andRelatedLysosomalStorageDiseases

73. PART IX

Lymphocytes and Plasma Cells

73.The StructureofLymphocytes andPlasma Cells

74.LymphopoiesisFunctionsof B LymphocytesandPlasma Cells inImmunoglobulinProduction

75. Functionsof T Lymphocytes:T-CellReceptorsforAntigen

76. FunctionsofNaturalKiller Cells

77. Classificationand Clinical ManifestationsofLymphocyteandPlasma Cell Disorders

79.LymphocytosisandLymphocytopenia

80.Immunodeficiency Diseases

81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome

82.MononucleosisSyndromes

PART X

MalignantMyeloid Diseases

83.Classification and ClinicalManifestationsoftheClonalMyeloidDisorders

84.PolycythemiaVera

85.EssentialThrombocythemia

86.Primary Myelofibrosis

87.MyelodysplasticSyndromes

88.AcuteMyelogenousLeukemia

89.ChronicMyelogenousLeukemiaandRelatedDisorders

PART XI

MalignantLymphoid Diseases

90.ClassificationofMalignantLymphoid Disorders

91.AcuteLymphoblasticLeukemia

92.ChronicLymphocyticLeukemia

93.Hairy Cell Leukemia

94.LargeGranularLymphocyticLeukemia

95.General ConsiderationsforLymphomas:Epidemiology， Etiology,Heterogeneity,and Primary Extranodal Disease

96.PathologyofLymphomas.

97.HodgkinLymphoma

98.Diffuse Large B-Cell Lymphoma andRelated Diseases

99.FollicularLymphoma

100.Mantle Cell Lymphoma

101.MarginalZone B-Cell Lymphomas

102.BurkittLymphoma

103.CutaneousT-CellLymphoma（MycosisFungoidesandSézarySyndrome）

104.MatureT-CellandNaturalKiller Cell Lymphomas

105.Plasma Cell Neoplasms: General Considerations

106.EssentialMonoclonalGammopathy

107.Myeloma.

108.ImmunoglobulinLight-ChainAmyloidosis

109.Macroglobulinemia.

110.Heavy-Chain Disease

PART XII

Hemostasis andThrombosis

111.Megakaryopoiesis andThrombopoiesis

112.PlateletMorphology，Biochemistry，and Function

113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasis

114.ControlofCoagulationReactions

115.VascularFunction in Hemostasis

116.Classification， Clinical Manifestations, andEvaluationofDisordersofHemostasis

117.Thrombocytopenia

118.Heparin-Induced Thrombocytopenia

119.ReactiveThrombocytosis

120.HereditaryQualitativePlateletDisorders

121.AcquiredQualitativePlateletDisorders

122.TheVascularPurpuras

123. Hemophilia A andHemophilia B

124. InheritedDeficiencies of Coagulation FactorsII，V，V VIII，VII，X，XI，and XII

125. Hereditary Fibrinogen Abnormalities

126. von Willebrand Disease

127. Antibody-Mediated Coagulation FactorDeficiencies

128. HemostaticAlterations in Liver Disease andLiverTransplantation

129. DisseminatedIntravascularCoagulation

130.HereditaryThrombophilia

131. The AntiphospholipidSyndrome

132. Thrombotic Microangiopathies

133.VenousThrombosis

134. Atherothrombosis: Disease Initiation，Progression，andTreatment

135. Fibrinolysis andThrombolysis

PART XIII

Transfusion Medicine

136. Erythrocyte AntigensandAntibodies

137. Human Leukocyte andPlateletAntigens

138. Blood Procurementand Red Cell Transfusion

139. Preservationand Clinical UseofPlatelets

Index